How to use the database

To search for a gene of interest, you simply have to go to the top and select "Get started" (or hit the Gene search tab on the top of the page). You can search for genes of interest by Gene (or synonyms), Ensembl ID, or description text. Then add these to a responsive table below with pagination pages and integrated search bar. The search input uses string in string, so you get all hits containing your input text. The table generated contains Ensembl ID, Gene, Synonyms, "Male TPM" (Expression of the gene in transcript per million), "Male Rank" (as ranked expression out of 15973 genes) "Female TPM", "Female Rank (out of 15880 genes)", "More info" (Additional information about the gene).
You can select genes of interest to the left and view these genes as expression plot by clicking the "Generate expression chart" at the bottom-right.

(The read more (not working) will be implemented soon)

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About the data

The data in the database originate from our study [Link to article]. Here you can read more about the methods used to create the underlying data. The "More info" tab utilizes data from Ensembl (www.ensembl.org) for full name and string-db (www.string-db.org) for description.

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The MacAulay Lab

The research group focuses on elucidation of the molecular mechanisms underlying water and ion homeostasis in the mammalian brain under both physiological and pathophysiological conditions.

Research Focus

Professor Nanna MacAulay and her research group study how the large quantity of water in the mammalian brain is continuously shifted between the circulating blood and the brain parenchyma as well as between different compartments and cellular structures within the brain tissue. One presumes that the transport of water between these different compartments is under tight control since a disturbance in the cerebral water homeostasis (potentially with associated changes in ion concentrations) may lead to neuronal dysfunction, hydrocephalus, and/or brain edema. However, the incomplete knowledge of the molecular mechanisms responsible for the maintenance of cerebral water transport and their regulation currently represents a knowledge gap in the research field. With this lack of identification of the implicated transport mechanisms and their dysregulation in pathology, pharmacological therapy is essentially unavailable for potentially life-threatening conditions involving brain water accumulation, i.e. hydrocephalus, brain edema, idiopathic intracranial hypertension, etc. The research group focuses on elucidation of the molecular mechanisms underlying cerebrospinal fluid secretion in the mammalian brain under both physiological and pathophysiological conditions.

The website was developed by PhD Student Søren Norge Andreassen, as a discovery tool for the scientific community to explore the gene expression of the rat choroid plexus.

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How to cite

All data is free to use for the scientific community, but please cite:

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Contact us

If you have any question, please address:

Nanna MacAulay

University of Copenhagen, Faculty of Health and Medical Sciences, Department of Neuroscience,
Blegdamsvej 3, DK-2200Copenhagen N, Denmark
E-mail: macaulay@sund.ku.dk

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